Brain disposition refers to the concept of how drugs or other substances are distributed and metabolized within the brain. This area of research focuses on understanding how various factors, such as blood-brain barrier permeability, metabolism by enzymes in the brain, and transporters within the brain, influence the levels of drugs or other substances in different regions of the brain. Studying brain disposition is important for understanding the pharmacokinetics and pharmacodynamics of drugs, as well as for developing new treatments for neurological disorders.